Especially the league's newest big money quarterback--Colin Kaepernick.
To be fair to Kaepernick he has not played a lot I any of the team's preseason games so he has not really had an opportunity to work his way in to a rhythm of any kind. However, while that can explain some things it does not explain all.
For example--ball protection. In the first two drives of Sunday's game against the Chargers he coughed up the ball. The 49ers only lost it once (his knee had already touched the ground on the other), but after giving him a bundle of money it has to be concerning.
Or maybe it is just the preseason being the preseason. How many times have we seen teams dominate during this time of year only to suck it big one the meaningful games started and vice versa?